Newly published clinical research in the Journal of Cosmetic Dermatology confirms nearly a decade of visible results with Pep Up® Collagen Boost Face & Neck Serum. In its third clinical study, this multi-peptide formula helps support collagen, improving resilience, and delivers visible skin improvements over time.
An Open-Label Study to Assess the Efficacy and Tolerability of a Multifunctional 10-Peptide Face and Neck Serum to Address Skin Quality
Kimberly Cayce MD, Kristen M. Jacobs, MD, Savanna Boda, LE, CLT
This 12-week study evaluated the effects of a 10-peptide anti-aging serum on skin quality and subject satisfaction in 48 subjects. Subjects were divided into two different groups based on prior use of medical-grade skincare, and applied the serum twice daily.
By week 12, nearly 90% of subjects showed significant improvement, with over half achieving moderate to marked results. The serum was well-tolerated, with high satisfaction, suggesting it enhances skin quality when added to basic skincare routines and professional skincare regimens.
This is a 28-year- old female subject from Group A at Baseline (left) and Week 12 (right).
Group A subjects used Pep Up® Collagen Boost Face & Neck Serum as their only professional-grade skincare regimen, which they were on for 90+ days.
Cayce K, Jacobs KM, Boda S. Journal of Cosmetic Dermatology, 2026. Results observed in a 12-week study with twice-daily use. Individual results may vary.
Clinically proven, peptide powered
This is a 52-year- old female subject from Group A at Baseline (left) and Week 12 (right).
Group A subjects used Pep Up® Collagen Boost Face & Neck Serum as their only professional-grade skincare regimen, which they were on for 90+ days.
Kimberly Cayce, MD Cayce Dermatology & Medical Spa. Results observed in a 12-week study with twice-daily use. Individual results may vary.
Results you can see
BeforeAfter
Before: baseline
After: after 12 weeks
Group B subjects incorporated Pep Up®into their existing professional grade skincare regimen which they were on for 90+ days.
Photo Credit: Kristen M. Jacobs, MD, Ooh La La Spa Anti-Aging & Wellness
BeforeAfter
Before: baseline
After: after 12 weeks
Group B subjects incorporated Pep Up®into their existing professional grade skincare regimen which they were on for 90+ days.
Photo Credit: Kimberly Cayce, MD, Cayce Dermatology & Medical Spa
96%
of subjects agreed that their skin looked and felt healthier
94%
of subjects agreed that their skin looked and felt more youthful
96%
of subjects demonstrated statistically significant global skin quality improvement
See what the experts are saying
In our 12-week published study of Pep Up® Collagen Boost Face & Neck Serum, 89.6% of subjects achieved statistically significant global improvement with twice-daily use, whether used alone or as part of a professional skin care regimen. We saw progressive improvement across all measured face and neck skin quality markers, with the most notable improvements in glow, firmness, crepiness, tone, oil balance, hyperpigmentation, and hydration. These results mirror what we see in clinical practice, and patients consistently comment on the serum’s cosmetically elegant feel.
Kimberly Cayce, MD
Cayce Dermatology Center and Medical Spa
What impressed me most in this study was the consistency of the results. All subjects in our center experienced improvement including increased hydration, reduced redness, visible softening of lines and wrinkles along with other markers of skin quality. This study further validates the Pep Up® Collagen Boost Face & Neck Serum results I see with my patients in clinic.
Kristen Jacobs, MD
Ooh La La Spa & Wellness
Having science-backed products I trust and confidently recommend is essential and what I built my business on. Being a part of this study allowed me to see firsthand how Pep Up® delivers significant improvements across key markers of skin quality. Results like these are exactly why evidence-based skincare is so important to the way I treat and educate.
